克罗米酚对男性低促性腺素精神分裂症减退症有效

纽约（里德社健康版）1同年四日刊文：据发表在12同年出版的《生孩子与不育》杂志的一项调查报告指出克罗米酮类对部分很低促性腺素性系统减退的年长高血压有利。来自伯明翰阿拉巴马大学的该调查报告的第一作者Scott J. Whitten哈佛大学在接受里德通讯社采访话说道：“恶性肿瘤或都将HH高血压在接受侵害性更大和更为昂贵的用药（例如注射促性腺激素类）之前进行时4个同年的克罗米酮类值得一提的是用药是有利的。”Whitten哈佛大学和同事深入研究了克罗米酮类对10名HH年长高血压（HH是导致年长不育的有名因素）应该有效。调查报告称克罗米酮类用药1年后，4名卡尔曼(赖)综合征高血压中会只有一名高血压的**含量上升而全卵巢系统减退症高血压的**不够症状均没有得到强化。相反，该调查报告指出3名刚出生肺癌的恶性肿瘤HH年长高血压经过3个同年克罗米酮类的用药**含量有了明显上升。目之前为止该组高血压就有两名直至了生孩子能力。Whitten哈佛大学说道：“除非对克罗米酮类用药没有反应，我们不会因为副作用停止对高血压使用该用药。”再一作者回顾说道：“因为情况下有限，对HH高血压促性腺激素类用药和克罗米酮类的随机深入研究难以进行时，然而利用多系列的严格为了让标准对高血压进行时PG可能帮助进一步验证克罗米酮类直至年长很低生孩子能力的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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编辑： 张靖